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PSMD3 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI2A2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525886

Catalog No. PIMA525886


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Description

Description

Proteolytic degradation is critical to the maintece of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman ft.s syndrome, and Liddle syndrome.
Specifications

Specifications

PSMD3
Monoclonal
0.95 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O43242, P14685
P58, RPN3, S3, TSTA2, 26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit RPN3, 26S proteasome regulatory subunit S3, proteasome subunit p58, tissue specific transplantation antigen 2
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
22123, 287670, 491018, 5709, 698712
Flow Cytometry, Western Blot
OTI2A2
Unconjugated
PSMD3
Liquid
PSMD3
Full length human recombit protein of PSMD3 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Non-human primate, Rat
Documents
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