Bmi-1 inhibitor (IC50 ~ 0.5µM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.
Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
CAS Number: 315704-66-6
Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
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