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PTCH Mouse anti-Human, Clone: OTI5C7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524893

Catalog No. PIMA524893


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Description

Description

A Sonic Hedgehog receptor, Patched1 is a polytopic receptor protein that is essential for growth and differentiation. It has been implicated in making an impact in the variation in tumor and response to therapy in ovarian cancer. Patched1 activates Smoothened (SMO) constitutively in cells; in Gorlin syndrome patients, blocking this interaction is a very effective way to cease formation of basal cell neoplasia. In addition to its availability in cell membrane fractions, Patched1 C-terminal fragments also function as a signal transducer to the cell nucleus. In inflammatory processes like ischemia-reperfusion injury, Patched1 is upregulated and can be seen in histologically damaged areas. In the common pediatric tumor medulloblastoma, Patched1 is an indicator of susceptibility.
Specifications

Specifications

PTCH
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q13635
PTCH1; PTCH; patched homolog (Drosophila); HGNC:9585; BCNS; HPE7; NBCCS; PTC; PTC1; patched; patched (Drosophila) homolog; patched homolog 1 (Drosophila); RP11-435O5.3; FLJ26746; FLJ42602; PTCH11; OTTHUMP00000021709; OTTHUMP00000021710; PTCH protein +12b; PTCH protein +4′; PTCH protein -10
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5727
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI5C7
Unconjugated
PTCH1
Liquid
PTCH1
Human recombit protein fragment corresponding to amino acids 122-436 of PTCH1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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