PTH Mouse anti-Human, Clone-SPM604, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP254434100UG

Catalog No. NB254434100

Description

PTH Monoclonal specifically detects PTH in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: PTH
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 0.5 - 1 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
• Gene Alias: Parathormone, Parathyrin, parathyroid hormone, parathyroid hormone 1, PTH1
• Host Species: Mouse
• Molecular Weight of Antigen: 9 kDa
• Quantity: 100 μg
• Research Discipline: Apoptosis, Biologically Active Proteins, Cancer
• Gene ID (Entrez): 5741
• Target Species: Human
• Isotype: IgG2b κ

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
• Clone: SPM604
• Conjugate: Unconjugated
• Formulation: PBS with No Preservative
• Gene Symbols: PTH
• Immunogen: A synthetic peptide from the N-terminal of human PTH polypeptide.
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
• Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.