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BBS9 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551315

Catalog No. PA551315


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Description

Description

The antibody detects endogenous levels of total PTHB1 / BBS9 protein.

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.
Specifications

Specifications

BBS9
Polyclonal
Unconjugated
BBS9
Liquid
BBS9
Fusion protein of human BBS9
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
0.8 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q3SYG4
PTHB1
Rabbit
IgG
100 μL
-20°C
Primary
27241
Documents
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