Tocris Bioscience PTIQ
Potent MMP-3 expression inhibitor; neuroprotective
Manufacturer: Tocris Bioscience 4604/50
DescriptionPotent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
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