Tocris™ PTIQ

Potent MMP-3 expression inhibitor; neuroprotective

Manufacturer: Tocris™ 4604/10

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Catalog No. 46-041-0

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For Research Use Only


    Inhibitors PTIQ
    Purity >98
    Molecular Weight 235.28
    Quantity 10mg
    Product Type PTIQ

    Potent inhibitor of MMP-3 expression (IC50 = 60nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.

    • Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
    • Formula: C13H17NO3
    • CAS Number: 1032822-42-6
    • Solubility: Soluble to 100mM in DMSO and to 20mM in 1eq. NaOH
    • Purity: >98

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