Potent MMP-3 expression inhibitor; neuroprotective
Manufacturer: Tocris 4604/50
DescriptionPotent inhibitor of MMP-3 expression (IC50 = 60nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
- Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
- Formula: C13H17NO3
- CAS Number: 1032822-42-6
- Solubility: Soluble to 100mM in DMSO and to 20mM in 1eq. NaOH
- Purity: >98
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