PTP1B Mouse anti-Human, Clone: OTI1A2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525574
DescriptionPTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PTP1B, protein tyrosine phosphatase 1B, protein tyrosine phosphatase, placental, protein-tyrosine phosphatase 1B, tyrosine-protein phosphatase non-receptor type 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Full length human recombit protein of PTPN1 produced in HEK293T cell|
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