PTPRB Monoclonal Antibody (122.2), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA15869

Catalog No. 01-674-947

Description

Predicted molecular weight: 224 kDa.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PTPRB
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: 0
• Gene Symbols: PTPRB
• Immunogen: Embryonic rat brain proteoglycans.
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgM

• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
• Clone: 122.2
• Conjugate: Unconjugated
• Gene: PTPRB
• Gene Alias: 3230402H02Rik; C130094E24; HPTPB; HPTP-BETA; protein tyrosine phosphatase, receptor type B; protein tyrosine phosphatase, receptor type, B; protein tyrosine phosphatase, receptor type, beta polypeptide; protein-tyrosine phosphatase beta; PTPB; Ptprb; Ptpz; receptor-type tyrosine-protein phosphatase beta; Rptpb; R-PTP-BETA; vascular endothelial protein tyrosine phosphatase; VEPTP; VE-PTP
• Host Species: Mouse
• Purification Method: Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 314843
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid