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Human PUMA, Synthetic Peptide, Invitrogen™

Synthetic Peptide

Manufacturer:  Invitrogen PEP0128

Catalog No. PEP0128


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Description

Description

PUMA Synthetic Peptide, PEP-0128, from Invitrogen.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. This peptide corresponds to 15 amino amino terminus of human PUMA.PEP-0128 can be used as a blocking peptide with polyclonal antibody PA5-20008.
Specifications

Specifications

Synthetic Peptide
purified
50μg
Blocking Assay, Control
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Human
RUO
0.02% sodium azide
BBC3
Blocking Assay, Control
27113
Human
200μg/mL
Liquid
N
PBS
-20°C
Human PUMA
Q96PG8
Peptide
Documents
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