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Puromycin, 10 mg/mL in distilled water, sterile-filtered, Alfa Aesar™

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Quantity:
1mL
5 x 1mL
53-79-2
C22H29N7O5
471.518
MFCD00012691
RXWNCPJZOCPEPQ-NVWDDTSBSA-N
439530
CHEBI:17939
(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O
53-79-2
C22H29N7O5
471.518
MFCD00012691
RXWNCPJZOCPEPQ-NVWDDTSBSA-N
439530
CHEBI:17939
(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O

Used as a substrate of Mdr-1. It is been widely used in cell culture applications.

Applications
Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.

Solubility
Soluble in water (50 mg/ml at 20°C).

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use. Optimal working concentration of puromycin varies between cell lines. Usually, the working concentration for eukaryote cell culture is 1-10 µg/ml
Physical Form Liquid
Concentration 10mg/mL in distilled water
Quantity 5 x 1mL
Chemical Name or Material Puromycin, sterile-filtered

GHS H Statement
H302
Harmful if swallowed.

GHS P Statement
P264-P270-P301+P312-P330-P501a
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Warning

RTECSNumber : AU7350000

storageNote1 : −30° to −10°C