Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered, Thermo Scientific Chemicals

Catalog Number AAJ67236XF
Click to view available options
Quantity:
1 mL
5 x 1 mL
58-58-2
C22H31Cl2N7O5
544.43
MFCD00150080
MKSVFGKWZLUTTO-MLYJQVMKNA-N
439530
CHEBI:17939
Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1
58-58-2
C22H31Cl2N7O5
544.43
MFCD00150080
MKSVFGKWZLUTTO-MLYJQVMKNA-N
439530
CHEBI:17939
Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

Puromycin (puromycine, CAS # 58-58-2) is a bacteriostatic antibiotic that acts as an aminoacyl-tRNA analog and disrupts protein synthesis.

Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Puromycin (puromycine) is an aminoglycoside antibiotic originating from Streptomyces alboniger
  • It acts as an aminoacyl tRNA analog and prematurely terminates peptide elongation
  • Puromycin has effects on both prokaryotes and eukaryotes
  • Puromycin may also have neoplastic activity

Application

  • Puromycin can be used for research use as an immunofluorescent target, in antibiotic resistance testing, or for studies on drug mechanisms
TRUSTED_SUSTAINABILITY
Type Puromycin dihydrochloride
Physical Form Liquid
Packaging Plastic Bottle
Solubility Information Soluble in water (50mg/ml at 20°C).
IUPAC Name (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
Quantity 1 mL
Chemical Name or Material Puromycin dihydrochloride
Hazard Category H302
Precautionary Statement P264b-P270-P301+P312-P330-P501c
RTECSNumber AU7350000
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit