PYCARD Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588132

Catalog No. PIPA588132

Description

Immunogen sequence: LDLTDKLVSF YLETYGAELT ANVLRDMGLQ EMAGQLQAAT HQGSGAAPAG IQAPPQSAAK PGLHFIDQHR AALIARVTNV EWLLDALYGK VLTDEQYQAV RAEPTNPSKM RKLFSFTPAW NWTCKDLLLQ ALRESQSYLV EDLERS; Positive Samples: A-549, THP-1; Cellular Location: Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PYCARD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PYCARD
• Gene Symbols: Pycard
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 50-195 of human PYCARD
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Concentration: 1.28 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9EPB4, Q9ULZ3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 282817, 29108, 66824
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid