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PYGL Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550479

Catalog No. PA550479


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Description

Description

The antibody detects endogenous levels of total PYGL protein.

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications

Specifications

PYGL
Polyclonal
Unconjugated
PYGL
Liquid
PYGL
Fusion protein corresponding to residues near the C terminal of human phosphorylase, glycogen, liver
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
P06737
GSD6
Rabbit
IgG
100 μL
-20°C
Primary
5836
Documents
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