PYGL Rabbit anti-Human, Polyclonal , Abnova™
Rabbit polyclonal antibody raised against recombinant human PYGL.
Manufacturer: Abnova Corporation PAB29353
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]Sequence: MRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSD
|Immunohistochemistry (1:500-1:1000) Immunofluorescence (1-4 ug/mL) Western Blot (1:250-1:500) The optimal working dilution should be determined by the end user.|
|Recombinant protein corresponding to human PYGL.|
|Antigen affinity purification|
|Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot|
|Rabbit polyclonal antibody raised against recombinant human PYGL.|
|In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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