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Tocris™ Pyridostatin pentahydrochloride

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

Manufacturer:  Tocris™ 4763/10

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Catalog No. 47-631-0


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Disclaimers:

For Research Use Only


Specifications

Description

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
  • Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
  • Formula: C31H32N8O5.5HCl
  • Solubility: Soluble to 100mM in water
  • Purity: >98
Description & Specifications

Specifications

Pyridostatin pentahydrochloride
>98
10mg
Pyridostatin pentahydrochloride
778.94
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