Tocris™ Pyridostatin pentahydrochloride

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

Manufacturer: Tocris™ 4763/10

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Catalog No. 47-631-0

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For Research Use Only


    Product Type Pyridostatin pentahydrochloride
    Inhibitors Pyridostatin pentahydrochloride
    Purity >98
    Molecular Weight 778.94
    Quantity 10mg

    Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

    • Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
    • Formula: C31H32N8O5.5HCl
    • Solubility: Soluble to 100mM in water
    • Purity: >98

  • Description & Specifications

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