Tocris Pyridostatin pentahydrochloride
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
Manufacturer: Tocris 4763/10
DescriptionBinds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
- Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
- Formula: C31H32N8O5.5HCl
- Solubility: Soluble to 100mM in water
- Purity: >98
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