Quinidine Monoclonal Antibody (QD14-504.5), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA110750

Catalog No. 01-671-980

Description

MA1-10750 detects Quinidine. MA1-10750 has been successfully used in ELISA applications. The MA1-10750 immunogen is Quinidine, conjugated to KLH.

Quinidine is an alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. [National Center for Biotechnology Information. PubChem Compound Database; CID=441074].

Specifications

• Antigen: Quinidine
• Classification: Monoclonal
• Concentration: 0.61 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: QD14-504.5
• Conjugate: Unconjugated
• Gene Alias: C20H24N2O2; Chinidin; Cin-Quin; Pitayine; Quinidex
• Immunogen: Quinidine, conjugated to KLH.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical