Tocris™ R 268712

Potent and selective inhibitor of TGF-betaRI

Manufacturer: Tocris™ 5288/50

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Catalog No. 52-885-0

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For Research Use Only


    Inhibitors R 268712
    Purity >98
    Molecular Weight 363.39
    Quantity 50mg
    Product Type R 268712

    Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5nM). Exhibits ~5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable.

    • Chemical Name: 4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol
    • Formula: C20H18FN5O
    • CAS Number: 879487-87-3
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >98

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