Tocris Bioscience™ ETP 45658 

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Manufacturer:  Tocris Bioscience™ 4702/10

Catalog No. 470210

Description

PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.

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Specifications

• Chemical Name or Material: ETP 45658
• Molecular Formula: C₁₆H₁₇N₅O₂
• Synonym: 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
• Solubility: Soluble to 100mM in DMSO
• Product Type: Bioactive Small Molecules

• CAS: 1198357-79-7
• Formula Weight: 311.34
• Quantity: 10mg
• Physical Form: Solid
• Purity: >98%

Safety and Handling

Recommended Storage : Store at +4°C.

Research Use Only. Not For Human or Veterinary Use