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Tocris Bioscience™ ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Manufacturer:  Tocris Bioscience™ 4702/10

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Catalog No. 470210


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Description

Description

ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.
Specifications

Specifications

>98%
311.34
Bioactive Small Molecule
1198357-79-7
10 mg
C16H17N5O2
Solid
ETP 45658
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Soluble to 100mM in DMSO
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

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