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Tocris Bioscience™ ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Manufacturer:  Tocris Bioscience™ 4702/50

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Catalog No. 470250


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Description

Description

ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.
Specifications

Specifications

Bioactive Small Molecule
Solid
C16H17N5O2
1198357-79-7
50 mg
311.34
>98%
ETP 45658
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Soluble to 100mM in DMSO
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

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