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Tocris Bioscience™ ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Manufacturer:  Tocris Bioscience™ 4702/50

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Catalog No. 470250


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Description

Description

PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.
Specifications

Specifications

ETP 45658
1198357-79-7
311.34
50mg
Solid
>98%
C16H17N5O2
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Soluble to 100mM in DMSO
Bioactive Small Molecules
Safety and Handling

Safety and Handling

Recommended Storage : Store at +4°C.

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