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Tocris Bioscience™ ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Specifications

Chemical Name or Material ETP 45658
CAS 1198357-79-7
Synonym 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Solubility Soluble to 100mM in DMSO
Molecular Formula C16H17N5O2
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
470210
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Tocris Bioscience™
4702/10
10 mg Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative. N/A
470250
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Tocris Bioscience™
4702/50
50 mg Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative. N/A
Description

Description

PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.
Specifications

Specifications

ETP 45658
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
C16H17N5O2
Solid
>98%
1198357-79-7
Soluble to 100mM in DMSO
311.34
Bioactive Small Molecule
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

SDS
Documents

Documents

Product Certifications

Research Use Only. Not For Human or Veterinary Use

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