R&D Systems Human CHIP Ubiquitin Ligase Kit - Glow-Fold Substrate
Designed for in vitro ubiquitination of user-supplied substrates by CHIP or the CHIP/HSP70/HSP40 ternary complex
Manufacturer: R&D Systems K280
CHIP (Carboxy terminus of HSP70-Interacting Protein) is a U-Box ubiquitin E3 ligase that ubiquitinates and mediates the proteasomal destruction of misfolded chaperone substrates. CHIP functions in coordination with several chaperone complexes, including HSP40, HSP70, and HSP90. CHIP activity may be modulated by the deubuiquitinase Ataxin-3, which restricts the length of ubiquitin chains attached to CHIP substrates and prevents further chain extension.
The resulting proteins can be used in downstream applications or analyzed by Western blot using antibodies specific for the target protein
|Store the unopened product at -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.|
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