R&D Systems Human HSP70/HSP40 Protein Refolding Kit
Provides a functional in vitro HSP70/HSP40 refolding system with included substrate protein or user-supplied proteins
Manufacturer: R&D Systems K290
The heat shock proteins are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. Some HSPs are expressed at low levels under normal physiological conditions but show dramatically increased expression in response to cellular stress, others are constitutively expressed. Specific HSPs play a role in regulating apoptosis by interacting directly with key components of the apoptotic pathway.
Using the provided substrate protein, the kit can be used to screen for small molecules affecting the efficiency of the refolding process (such as HSP inhibitors)
Alternatively, the HSP70/HSP40 complex may be used to test refolding of user-supplied proteins if a functional assay is available
|Store the unopened product at -70° C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.|
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