Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

R&D Systems Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate

Designed for the in vitro ubiquitination of p53 by MDM2 with subsequent Western blot

Manufacturer:  R&D Systems K200B

Catalog No. K200B

Add to cart
This item is not returnable. View return policy



The RING-finger ubiquitin E3 ligase MDM2 (Murine Double Minute 2) is an important regulator of the tumor suppressor protein p53. MDM2 ligase activity is at least partially responsible for the ubiquitination and subsequent proteasomal degradation of p53.

Ubiquitinated proteins can be used in downstream applications, or analyzed by Western blot using antibodies specific for the target protein
This kit can be used as a positive control in studies that monitor the activities of other known or putative E3 ligase enzymes that ubiquitinate p53
Ubiquitinated p53 substrate can also be used to study E4 ligase activities of enzymes such as UBE4B, or the activity of deubiquitinating enzymes such as USP7



Store the unopened product at -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
1 Kit
Product Certifications


Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit