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R&D Systems Human MuRF1/TRIM63 Ubiquitin Ligase Kit, S5a Substrate

Designed for in vitro MuRF1-mediated ubiquitination of user-supplied substrates such as cardiac troponin 1, MYH7, or muscle creatine kinase

Manufacturer:  R&D Systems K102

Catalog No. K102

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MuRF1 (Muscle-specific RING-finger protein 1) is a RING-finger E3 ligase found in striated muscle (heart and skeletal) and iris tissues. The protein contains both RING and B-box zinc fingers, and a coiled-coil tripartite fold known as TRIM. MuRF1 ligase activity regulates the proteasomal degradation of cardiac troponin 1 and other sarcomeric-associated proteins.

Ubiquitinated proteins can be used in downstream applications, or analyzed by Western blot using antibodies specific for the target protein



Store the unopened product at -70° C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Angiocidin, ASF, EC 6.3.2.-, IRF, IRFMURF2, Iris RING finger protein, Macropain, Mcb1, MuRF1, MuRF-1, muscle specific ring finger protein 2, Muscle-specific RING finger protein 1, PSMD4, pUB-R5, RING finger protein 28FLJ32380, RNF28, RNF28E3 ubiquitin-pro
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