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R&D Systems Maritoclax, Tocris™

Mcl-1 inhibitor; disrupts Mcl-1-Bim interaction and induces Mcl-1 proteasomal degradation

Manufacturer:  R&D Systems 5368/10

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Catalog No. 536810


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Disclaimers:

Research Use Only. Not For Human or Veterinary Use


Specifications

Description

  • Exhibits no effect on Bcl-XL-Bim interaction
  • Selectively induces apoptosis in Mcl-1-dependent K562 leukemia cells
  • Sensitizes K562 and Raji cells to ABT-737-induced apoptosis
Description & Specifications

Specifications

Maritoclax
>97%
510.15
10mg
Solid
1227962-62-0
C22H12Cl4N2O4
1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-2-hydroxyphenyl)methanone
Soluble to 100mM in DMSO and to 50mM in ethanol
Bioactive Small Molecules

Safety and Handling

Recommended Storage : Store at -20°C.

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