R&D Systems Maritoclax, Tocris™

Mcl-1 inhibitor; disrupts Mcl-1-Bim interaction and induces Mcl-1 proteasomal degradation

Manufacturer: R&D Systems 5368/50

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Catalog No. 536850

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Research Use Only. Not For Human or Veterinary Use


    Chemical Name or Material Maritoclax
    CAS 1227962-62-0
    Assay Percent Range >97%
    Molecular Formula C22H12Cl4N2O4
    Formula Weight 510.15
    Synonym 1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-2-hydroxyphenyl)methanone
    Recommended Storage Store at -20°C.
    Quantity 50mg
    Solubility Soluble to 100mM in DMSO and to 50mM in ethanol
    Physical Form Solid
    Product Type Bioactive Small Molecules

    • Exhibits no effect on Bcl-XL-Bim interaction
    • Selectively induces apoptosis in Mcl-1-dependent K562 leukemia cells
    • Sensitizes K562 and Raji cells to ABT-737-induced apoptosis

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