R&D Systems PARP Enzyme High Specific Activity

Purified from E. coli containing a recombinant plasmid harboring the human PARP gene

Manufacturer: R&D Systems 4668-500-01

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Catalog No. 466850001

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    Product Name Poly [ADP-ribose] Polymerase Enzyme High Specific Activity
    Quantity 500μL

    PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89 and 24kDa in one of the hallmark events of apoptosis.

    • One unit of PARP incorporates 10femtomoles of NAD onto immobilized histones in 30 minutes
    • High specific activity PARP is provided at 10 units/µL

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