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  5. Tocris Bioscience™ Zosuquidar Trihydrochloride
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Tocris Bioscience™ Zosuquidar Trihydrochloride

High affinity P-gp inhibitor

Supplier:  Tocris Bioscience™ 5456/10

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Catalog No. 545610


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Description

Description

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.
Specifications

Specifications

Zosuquidar trihydrochloride
(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
Soluble to 50mM in DMSO
636.99
Bioactive Small Molecule
167465-36-3
10 mg
C32H31F2N3O2·3HCl
Solid
97%
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Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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