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Tocris Bioscience™ (R)-DRF053 dihydrochloride

Name: Tocris Bioscience&trade; (R)-DRF053 dihydrochloride
Brand: Tocris Bioscience&trade;
SKU: 36-101-0R
Price: 358.44 USD

Potent CK1 inhibitor; also inhibits cyclin-dependent kinases

Supplier: Tocris Bioscience™ 3610/10

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Catalog No. 36-101-0R

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Description

(R)-DRF053 dihydrochloride is a potent casein kinase 1 (CK1) inhibitor (IC50 = 14 nM). Also an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (IC50 values are 0.093 - 0.29, 0.21 and 0.82 μM for cdk2, cdk5 and cdk7, respectively). Shown to inhibit amyloid-β production in N2A-APP695 cells.

Specifications

Purity	>98%
Product Type	(R)-DRF053 dihydrochloride
Inhibitors	(R)-DRF053 dihydrochloride

Quantity	10 mg
Molecular Weight (g/mol)	490.43

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Tocris Bioscience™ (R)-DRF053 dihydrochloride

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