R&D Systems Recombinant Mouse Activin B

INHBB; Inhibin, Beta B; Inhibin, Beta-2

Manufacturer: R&D Systems 8260AB010/CF

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Catalog No. 82-60A-B010CF

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    Specifications

    Accession Number Q04999
    Concentration Reconstitute at 100μg/mL in sterile 4mM HCl.
    Conjugate Unlabeled
    Formulation Lyophilized from a 0.2μm filtered solution in HCl.
    Molecular Weight 13 kDa (monomer)
    Name Activin B, Carrier Free
    Purity >95%, by SDS-PAGE with silver staining.
    Quantity 10μg
    Recombinant Yes
    Source Mouse

    Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.

    Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B).

  • Description & Specifications

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