RAB21 Monoclonal Antibody (OTI6H8), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA505746

Catalog No. 50-167-6176

Description

RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.

Specifications

• Antigen: RAB21
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9UL25
• Gene Symbols: RAB21
• Immunogen: Full length human recombit protein of human RAB21 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: OTI6H8
• Conjugate: Unconjugated
• Gene: RAB21
• Gene Alias: KIAA0118
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23011
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid