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RAB21 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548566

Catalog No. PA548566

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with bovine, mouse and rat based on sequence homology.

RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.
Specifications

Specifications

RAB21
Polyclonal
PBS with 0.09% sodium azide
Q9UL25
Ras-related protein Rab-21, RAB21, KIAA0118
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23011
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RAB21
Liquid
RAB21
KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human RAB21.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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