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RAB3A Mouse anti-Human, Clone: OTI5C12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527178

Catalog No. PIMA527178


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Description

Description

Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals and the best studied is rab 3A. Rab 3A is found to be abundant in presynaptic nerve terminals and is also found to be crucial in acrosomal exocytosis in human spermatozoa. Abnormal accumulation of rab 3A in the cytoplasm of Purkinje cells has been reported in the prion protein related Creutzfeldt-Jakob disease.
Specifications

Specifications

RAB3A
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P20336
Ras-Associated Protein 3A
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5864
Immunohistochemistry (Paraffin), Western Blot
OTI5C12
Unconjugated
RAB3A
Liquid
RAB3A
Full length human recombit protein of RAB3A produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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