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RAB8A Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550483

Catalog No. PA550483


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Description

Description

The antibody detects endogenous levels of total RAB8A protein.

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and maligt melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
Specifications

Specifications

RAB8A
Polyclonal
Unconjugated
RAB8A
Liquid
RAB8A
Synthetic peptide corresponding to a region derived from internal residues of human Ras-related protein Rab-8A
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
P61006
MEL, RAB8
Rabbit
IgG
100 μL
-20°C
Primary
4218
Documents
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