MilliporeSigma™ Rabbit anti-acetyl-Histone H3 (Lys79), Clone: RM156,

Rabbit Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE642

Catalog No. MABE642MI

Description

Specifically detects acetyl-Histone H3 (Lys79) clone: RM156 in Human samples, and it is validated for Western Blotting

Histone H3, also known as Histone H3.1t (H3/t), H3t, H3/g, and encoded by the gene name HIST3H3/ H3FT, is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Therefore, histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. High levels of phosphorylation of Histone H3 are associated with mitosis.

Specifications

• Antigen: acetyl-Histone H3 (Lys79)
• Classification: Monoclonal
• Formulation: Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide.
• Gene Symbols: H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B
• Immunogen: A linear peptide corresponding to human Histone H3 acetylated at Lys79.
• Quantity: 100 μg
• Research Discipline: Epigenetics and Nuclear Function
• Target Species: Human
• Form: Purified

• Applications: Western Blot
• Clone: RM156
• Gene Accession No.: P84243
• Host Species: Rabbit
• Purification Method: Protein A Purfied
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
• Isotype: IgG

For Research Use Only