AR Rabbit anti-Human, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of AR.
Manufacturer: Abnova Corporation PAB26684
The androgen receptor gene is more than 90kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeqSequence: T-T-Sp-P-T
|Rabbit polyclonal antibody raised against synthetic peptide of AR.|
|In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.|
|A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S650 of human AR.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
For Research Use Only