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BCR (phospho Y177), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of BCR.

Manufacturer:  Abnova Corporation PAB25329

Catalog No. 89-126-982


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Description

Description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: P-F-Yp-V-N
Specifications

Specifications

BCR
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
BCR
Liquid
BCR
Synthetic phosphopeptide corresponding to residues surrounding Y177 of human BCR.
100 ug
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
Human, Murine
Immunohistochemistry (PFA fixed), Western Blot
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BCR.
In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
P11274
ALL|BCR-ABL1|BCR1|CML|D22S11|D22S662|FLJ16453|PHL
Rabbit
Affinity purification
RUO
Primary
613
SDS
Documents
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