BCR (phospho Y177), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of BCR.

Manufacturer:  Abnova Corporation PAB25329

Catalog No. 89-126-982

Description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: P-F-Yp-V-N

Specifications

• Antigen: BCR
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
• Gene: BCR
• Format: Liquid
• Gene Symbols: BCR
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Y177 of human BCR.
• Quantity: 100 ug
• Storage Requirements: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Murine

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of BCR.
• Formulation: In PBS (without mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Accession No.: P11274
• Gene Alias: ALL|BCR-ABL1|BCR1|CML|D22S11|D22S662|FLJ16453|PHL
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 613

For Research Use Only