CIITA Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.
Manufacturer: Abnova Corporation PAB19313
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the ''master control factor'' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq
|Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.|
|In PBS (0.02% sodium azide)|
|Peptide affinity purification|
|ELISA, Immunohistochemistry, Western Blot|
|Western Blot (1 ug/mL) Immunohistochemistry (10 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to 16 amino acids near N-terminus of human CIITA.|
|Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Human, Murine, Rat|
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