CIITA Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.

Manufacturer:  Abnova Corporation PAB19313

Catalog No. 89-120-846

Description

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the ''master control factor'' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq

Specifications

• Antigen: CIITA
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.
• Formulation: In PBS (0.02% sodium azide)
• Gene Accession No.: P33076
• Gene Alias: C2TA|CIITAIV|MHC2TA|NLRA
• Host Species: Rabbit
• Purification Method: Peptide affinity purification
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4261

• Applications: ELISA, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) Immunohistochemistry (10 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: CIITA
• Format: Liquid
• Gene Symbols: CIITA
• Immunogen: A synthetic peptide corresponding to 16 amino acids near N-terminus of human CIITA.
• Quantity: 100 ug
• Storage Requirements: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Murine, Rat

For Research Use Only