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CIITA Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.

Manufacturer:  Abnova Corporation PAB19313

Catalog No. 89-120-846


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Description

Description

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the ''master control factor'' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq

Specifications

Specifications

CIITA
1 mg/mL
Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.
In PBS (0.02% sodium azide)
P33076
C2TA|CIITAIV|MHC2TA|NLRA
Rabbit
Peptide affinity purification
RUO
Primary
4261
ELISA, Immunohistochemistry, Western Blot
Unconjugated
Western Blot (1 ug/mL) Immunohistochemistry (10 ug/mL) The optimal working dilution should be determined by the end user.
CIITA
Liquid
CIITA
A synthetic peptide corresponding to 16 amino acids near N-terminus of human CIITA.
100 ug
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
Human, Murine, Rat
SDS
Documents
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