EIF4E Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of EIF4E.
Supplier: Abnova Corporation PAB5342
All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24kDa polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50kDa polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220kDa polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).[supplied by OMIM
|Rabbit polyclonal antibody raised against synthetic peptide of EIF4E.
|In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
|Human, Mouse, Rat
|Immunohistochemistry (PFA fixed), Western Blot
|Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
|A synthetic peptide corresponding to residues surrounding S209 of human EIF4E.
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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