Estrogen Receptor beta Rabbit anti-Human, Polyclonal, Invitrogen™  

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 517700

Catalog No. 51-770-0

Description

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms domitly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

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Specifications

• Antigen: Estrogen Receptor beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ESR2
• Format: Liquid
• Gene Symbols: ESR2
• Immunogen: A 19 amino acid synthetic peptide derived from the C-terminus of the human Estrogen Receptor-beta protein.
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: ELISA, Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: Q92731
• Gene Alias: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μg
• Storage Requirements: -20°C
• Primary or Secondary: Primary
• Gene ID (Entrez): 2100