MAP2K3 Rabbit anti-Human, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MAP2K3.

Manufacturer:  Abnova Corporation PAB19110

Catalog No. 89-120-642

Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq

Specifications

• Antigen: MAP2K3
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL) Immunocytochemistry (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: MAP2K3
• Gene Alias: MAPKK3|MEK3|MKK3|PRKMK3
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 ug
• Storage Requirements: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water to a concentration of 500μg/mL
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Rat

• Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MAP2K3.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Format: Lyophilized
• Gene Symbols: MAP2K3
• Immunogen: A synthetic peptide corresponding to C-terminus of human MAP2K3.
• Purification Method: Immunoaffinity purification
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5606

For Research Use Only