MAP2K3 Rabbit anti-Human, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MAP2K3.

Manufacturer:  Abnova Corporation PAB19110

Catalog No. 89-120-642

Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq

Specifications

• Antigen: MAP2K3
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MAP2K3.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene Alias: MAPKK3/MEK3/MKK3/PRKMK3
• Host Species: Rabbit
• Purification Method: Immunoaffinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5606
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL) Immunocytochemistry (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: MAP2K3
• Gene Symbols: MAP2K3
• Immunogen: A synthetic peptide corresponding to C-terminus of human MAP2K3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Isotype: IgG

For Research Use Only