MMP25, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-131-578	400 μL

Catalog No. 89-131-578 Supplier Abnova Corporation Supplier No. PAB4790

Description

Rabbit polyclonal antibody raised against synthetic peptide of MMP25.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq

Specifications

• Antigen: MMP25
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MMP25.
• Dilution: ELISA (1:1000) Western Blot (1:100-500) Flow cytometry (1:10-50) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: MMP25
• Gene Alias: MMP20/MMP20A/MMPL1/MT-MMP6/MT6-MMP
• Gene Symbols: MMP25
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MMP25.
• Purification Method: Protein G purification
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 64386
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only