PLAU Rabbit anti-Human, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against recombinant PLAU.
Supplier: Abnova Corporation PAB5117
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
|Rabbit polyclonal antibody raised against recombinant PLAU.
|In PBS, pH 7.5 (50% glycerol, 0.01% thimerosal)
|ELISA, Immunoprecipitation, Western Blot
|The optimal working dilution should be determined by the end user.
|Recombinant protein corresponding to human PLAU.
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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