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Rabbit anti-PTEN, Polyclonal, Novus Biologicals™

Rabbit Polyclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2445380.1MG

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Catalog No. NBP24453801



Description

Description

Specifically detects PTEN in Human, Mouse samples, and it is validated for Flow Cytometry, Immunofluorescence, Western Blotting

PTEN Polyclonal antibody specifically detects PTEN in Human, Mouse samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

PTEN
0.2mg/mL
Western Blot 0.5 - 1.0 ug/ml, Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 1:10-1:500, Immunofluorescence 1 - 2 ug/ml
P60484
BZS, EC 3.1.3.16,10q23del, EC 3.1.3.48, EC 3.1.3.67, GLM2, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1MGC11227, Mutated in multiple advanced cancers 1, phosphatase and tensin homologDEC, phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN, PTEN1, TEP1MHAM
Rabbit
IgG
Protein A purified
RUO
Primary
5728
Human, Mouse
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
PTEN
Recombinant full-length human PTEN protein
55 kDa
0.1 mg
Store at 4C.
Polyclonal
Recognizes a protein of 55kDa, which is identified as PTEN. PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage. Furthermore, PTEN mutation also causes a variety of inherited predispositions to cancer.
Documents
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