RPS6KB1 (phospho T421), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of RPS6KB1.

Manufacturer:  Abnova Corporation PAB25842

Catalog No. 89-127-471

Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq

Sequence: P-R-T-P-V

Specifications

• Antigen: RPS6KB1
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of RPS6KB1.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Format: Liquid
• Gene Symbols: RPS6KB1
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding T421 of human RPS6KB1.
• Quantity: 100 ug
• Storage Requirements: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Murine, Rat

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
• Gene: RPS6KB1
• Gene Alias: PS6K|S6K|S6K1|STK14A|p70(S6K)-alpha|p70-S6K|p70-alpha
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6198

For Research Use Only