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SMAD1 (phospho S206), Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of SMAD1.

Manufacturer:  Abnova Corporation PAB16903

Catalog No. 89-118-715

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The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq



Rabbit polyclonal antibody raised against synthetic phosphopeptide of SMAD1.
In 20mM KH2PO4, 150mM NaCl, pH 7.2 (0.01% sodium azide)
100 μg
Reactivity occurs against human SMAD1 phosphoS206 protein and This antibody is specific to the phosphorylated form of the protein. Reactivity with non-phosphorylated human SMAD1 is minimal by ELISA and western blot.
ELISA, Western Blot
ELISA (1:5000-1:25000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
Synthetic phosphopeptide corresponding to residues surrounding to S206 of human SMAD1.
Canine, Human, Mouse, Rat
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