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RAD18 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 183331AP150UL

Encompass_Preferred

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Catalog No. 50-173-2120


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Description

Description

This antibody is specific to RAD18.

Human Rad18 (hRad18) is homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif. It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6. The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.
Specifications

Specifications

RAD18
Polyclonal
Unconjugated
RAD18
hHR18, hRAD18, RAD18, RAD18 homolog (S. cerevisiae), RING finger protein 73, RNF73
Rabbit
Antigen Affinity Chromatography
RUO
362412, 56852, 58186
-20°C
Liquid
Western Blot
0.3 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NS91, Q9QXK2
Rad18
RAD18 Fusion Protein Ag12944
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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