RAD18 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 183331AP
This antibody is specific to RAD18.Human Rad18 (hRad18) is homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif. It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6. The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|hHR18, hRAD18, RAD18, RAD18 homolog (S. cerevisiae), RING finger protein 73, RNF73|
|362412, 56852, 58186|
|RAD18 Fusion Protein Ag12944|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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